Analyseit
http://analyseit.com/blog/
Analyseit statistical analysis and visualization software blog. Provides the latest news, releases, upcoming new features and informative articles so you get the most out of Analyseit and Microsoft Excel.
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http://analyseit.com//blog/2015/9/analyseit420releasedsupportforexcel2016
Analyseit 4.20 released: Support for Excel 2016
http://feeds.analyseit.com/~r/Analyseit/~3/AO8LwdEUHbk/analyseit420releasedsupportforexcel2016
<div class="article">
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<p><img src="http://analyseit.com/assets/article/54611640/Office2016sm.png" style="float:right">
Microsoft officially released <a href="https://products.office.com/" target="_blank">Office 2016</a> a couple of days ago, and Analyseit version 4.20 now adds support for Excel 2016. </p>
<p>Over the next few weeks we will tweak the Analyseit user interface so it matches the new Office 2016 user interface styles. Line styles on the plots in Excel 2016 now also appear a lot thicker, due to antialiasing (smoothing), so we will decide whether to address that in a future update – let us know what you think.</p>
<p>If you have <a href="http://analyseit.com/docs/300/userguide/concepts/maintainance" target="_blank">active maintenance</a> you can download and install the update now, see <a href="http://analyseit.com/docs/300/userguide/concepts/softwareupdates" target="_blank">updating the software</a>. If maintenance on your licence has expired you can renew it to get this update and forthcoming updates, see <a href="http://analyseit.com/store/maintenance/" target="_blank">renew maintenance</a>.</p>
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Releases
Excel
Thu, 24 Sep 2015 11:15:17 GMT
http://analyseit.com//blog/2015/9/analyseit420releasedsupportforexcel2016

http://analyseit.com//blog/2015/8/thenumericalaccuracyofanalyseitagainsttheniststrd
The numerical accuracy of Analyseit against the NIST StRD
http://feeds.analyseit.com/~r/Analyseit/~3/gyZeEkrtvCc/thenumericalaccuracyofanalyseitagainsttheniststrd
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<p>A critical feature of any analytical and statistical software is accuracy. You are making decisions based on the statistics obtained and you need to know you can rely on them.</p>
<p>We have documented our <a href="http://analyseit.com/blog/2014/1/oursoftwaredevelopmentandvalidationprocess">software development and validation process</a> previously, but another good benchmark to test statistical software against is the NIST StRD. The Statistical Engineering and Mathematical and Computational Sciences Divisions of NIST’s Information Technology Laboratory developed datasets with certified values for a variety of statistical methods against which statistical software packages can be benchmarked. <span style="fontfamily: Arial, Helvetica, Verdana, Tahoma, sansserif; fontsize: 15px; lineheight: 1.45em; backgroundcolor: initial;">The certified values are computed using ultrahigh precision floating point arithmetic and are accurate to 15 significant digits.</span></p>
<p>For more information about the NIST StRD see:</p>
<img src="http://www.itl.nist.gov/div898/strd/general/gifs/strd80.gif">
<p><a href="http://www.itl.nist.gov/div898/strd/" target="_blank">http://www.itl.nist.gov/div898/strd/</a></p>
<p><span style="fontfamily: Arial, Helvetica, Verdana, Tahoma, sansserif; fontsize: 15px; lineheight: 1.45em; backgroundcolor: initial;">We tested version 4.00 of Analyseit against the NIST StRD on an Intel Xeon dual processor PC.</span><br>
</p>
<p>No statistical package achieves perfect accuracy for all the tests and no one package performs best for every test. Most statistical packages use IEEE754 double precision (64bit) floating point arithmetic and due to finite precision, roundoff, and truncation errors in numerical operations, are unable to obtain the exact certified value.</p>
<p>In the tests:</p>
<ul>
<li><b>Analyseit performed consistently amongst the best on all tests.</b></li>
<li><b>Analyseit performed better than some of the most popular wellknown statistical packages</b>.</li>
</ul>
<p>For more information on the performance of Analyseit against the NIST StRD, and to download the workbooks containing the analyses, see:</p>
<p><a href="http://analyseit.com/support/NISTStRD">http://analyseit.com/support/NISTStRD</a></p>
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Statistics
Business
Tue, 11 Aug 2015 11:36:43 GMT
http://analyseit.com//blog/2015/8/thenumericalaccuracyofanalyseitagainsttheniststrd

http://analyseit.com//blog/2015/6/analyseit40releasedsupportforclsiguidelinesandmeasurementsystemsanalysis
Analyseit 4.0 released: Support for CLSI guidelines, and Measurement Systems Analysis
http://feeds.analyseit.com/~r/Analyseit/~3/yZ2W6VPkcs4/analyseit40releasedsupportforclsiguidelinesandmeasurementsystemsanalysis
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<p>Today we released version 4.0 of the Analyseit Method Validation edition. This is a major new release with many new features and improvements.</p>
<h2>Support for 10 of the latest CLSI EP guidelines</h2>
<p>The latest release of the Analyseit Method Validation edition now supports 10 of the latest CLSI evaluation protocol (EP) guidelines. <a href="http://clsi.org" target="_blank">CLSI</a> guidelines are worldrenowned and are recognized by the College of American Pathologists (CAP), The Joint Commission, and the US Food and Drug Administration (FDA).</p>
<p>Analyseit has been a driving force in the adoption of statistics in method validation for over 15 years, has influenced many recommendations, and is the only software available with such extensive coverage for the latest CLSI guideles.</p>
<p>CLSI guidelines supported in version 4.0 include:</p>
<table class="table small">
<tbody>
<tr>
<td class=""><a href="http://shop.clsi.org/methodevaluationdocuments/EP05.html" target="_blank">EP05A3</a><br>
Evaluation of Precision of Quantitative Measurement Procedures </td>
</tr>
<tr>
<td class="redactorcurrenttd"><a href="http://shop.clsi.org/methodevaluationdocuments/EP06.html" target="_blank">EP06A</a><br>
Evaluation of the Linearity of Quantitative Measurement Procedures </td>
</tr>
<tr>
<td class=""><a href="http://shop.clsi.org/methodevaluationdocuments/EP09.html" target="_blank">EP09A3</a><br>
Measurement Procedure Comparison and Bias Estimation Using Patient Samples </td>
</tr>
<tr>
<td><a href="http://shop.clsi.org/methodevaluationdocuments/EP10.html" target="_blank">EP10A3AMD</a><br>
Preliminary Evaluation of Quantitative Clinical Laboratory Measurement Procedures </td>
</tr>
<tr>
<td><a href="http://shop.clsi.org/methodevaluationdocuments/EP12.html" target="_blank">EP12A2</a><br>
User Protocol for Evaluation of Qualitative Test Performance </td>
</tr>
<tr>
<td><a href="http://shop.clsi.org/methodevaluationdocuments/EP15.html" target="_blank">EP15A3</a><br>
User Verification of Precision and Estimation of Bias </td>
</tr>
<tr>
<td class=""><a href="http://shop.clsi.org/methodevaluationdocuments/EP17.html" target="_blank">EP17A2</a><br>
Evaluation of Detection Capability for Clinical Laboratory Measurement Procedures </td>
</tr>
<tr>
<td><a href="http://shop.clsi.org/methodevaluationdocuments/EP21.html" target="_blank">EP21A</a><br>
Estimation of Total Analytical Error for Clinical Laboratory Methods </td>
</tr>
<tr>
<td class=""><a href="http://shop.clsi.org/methodevaluationdocuments/EP24.html" target="_blank">EP24A2 (Replaces GP10A)</a><br>
Assessment of the Diagnostic Accuracy of Laboratory Tests Using Receiver Operating Characteristic Curves </td>
</tr>
<tr>
<td class=""><a href="http://shop.clsi.org/methodevaluationdocuments/EP28.html" target="_blank">EP28A3C (Formerly C28A3C)</a><br>
Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory </td>
</tr>
</tbody>
</table>
<h2>Measurement Systems Analysis (MSA)</h2>
<p>Measurement Systems Analysis (MSA) is a new feature in version 4.0. MSA unifies precision and linearity, which were available in earlier versions of Analyseit, but also includes trueness (bias) and detection capability so you can establish the limit of blank (LoB) and limit of detection (LoD). The unification of these analyses in MSA lets you dig deep to examine and understand the performance characteristics of a measurement procedure.</p>
<p><img src="http://analyseit.com/assets/article/54611638/Precision profile.PNG" style="cursor: default;"></p>
<p><img src="http://analyseit.com/assets/article/54611638/Trueness.PNG" style="cursor: default;"></p>
<p><img src="http://analyseit.com/assets/article/54611638/Detection limit.PNG" style="cursor: default;"></p>
<h2>Partition Method Comparison and Reference Interval analyses</h2>
<p>A major improvement in version 4.0 is the ability to split a method comparison analysis into specific measuring intervals and apply a different analysis. For example, you might split the analysis into two measuring intervals: samples <1ug/L, and those above. For <1ug/L the relationship between measurements might be different from those >1 ug/L, so you can apply different fits and goals to each measuring interval to see how the methods compare.</p>
<p>Similarly, for reference intervals you can apply partitioning factors to generate reference intervals for different subgroups. For example, you might apply partitioning factors sex and age group so you can determine reference intervals for age groups 020, 2035, 3550, and 50+ for male / female subjects. For each subgroup you can change how the reference interval is calculated, for example using the robust reference interval calculation for a subgroup with very few subjects.</p>
<p><img src="http://analyseit.com/assets/article/54611638/Method comparision.PNG" style="cursor: default;"></p>
<h2>Availability</h2>
<p>If you already have a licence for Analyseit, and you have active maintenance (access to software updates), you can download the latest version now. If maintenance on your licence has lapsed, now is a good time to renew maintenance to get this update and future updates before the price increase (see below). </p>
<p>To download the update, check whether you have maintenance, or to renew maintenance, see:</p>
<p><a href="http://analyseit.com/support/download" target="_blank">http://analyseit.com/support/download</a></p><p>If you are new to Analyseit you can download a free 30day trial at:</p><p><span style="fontfamily: Arial, Helvetica, Verdana, Tahoma, sansserif; fontsize: 15px; lineheight: 1.45em; backgroundcolor: initial;"><a href="http://analyseit.com/products/methodvalidation/try">http://analyseit.com/products/methodvalidation/try</a></span></p>
<h2>Pricing and licensing changes from 7th July 2015</h2>
<p>The cost of a 1user perpetual licence for the Analyseit Method Validation will increase from US$699 to US$749, and the cost of a 1 floatinguser perpetual licence will crease from US$1239 to US$1329 from the 7th July 2015. Since maintenance is based on a percentage of the licence price, the 1year maintenance renewal price for a 1user perpetual licence will increase slightly from US$69.90 to US$74.90.</p>
<p>We will also be trialling a new option to purchase a 1year annual subscription for the Analyseit Method Validation edition from the 7th July 2015. The cost will be US$ 449 for 1year and includes all software updates released within the year. At the end of the year you can renew your licence to continue using the software, or let the licence lapse if you no longer need it.</p>
<h2>Change summary</h2>
<p>Finally, below is a list of the major changes and improvements in version 4.0.</p>
<p><b>Reference interval</b></p>
<ul>
<li>Partition factors for separate reference interval analysis of subgroups.</li>
<li>Additional transformation functions: Manly exponential, 2stage Exponential/Modulus transformation.</li>
<li>Normal MVUE quantile estimator for reference limits.</li>
</ul>
<p><b>Diagnostic performance</b></p>
<ul>
<li>BiHistogram and dotpot of the distribution of positive/negative cases.</li>
</ul>
<p><b>Method comparison</b></p>
<ul>
<li>Adjust measuring interval to a linear range and extrapolate fits beyond the data to the measuring interval.</li>
<li>Partition into measuring intervals, with different relationships (e.g. constant / relative differences or variances) for each measuring interval.</li>
</ul>
<p><b>Linearity</b></p>
<ul>
<li>Improved report and plots.</li>
<li>Integrated into MSA to allow unified approach to evaluation of other components of error.</li>
</ul>
<p><b>Precision</b></p>
<ul>
<li>Improved report and plots.</li>
<li>Precision profile variance function fits with a choice of 7 fits, including Sadler 3parameter functions.</li>
<li>Limit of quantitation via prediction from CV% on precision profile plot.</li>
</ul>
<p><b>Trueness <span class="label labelimportant">NEW</span></b></p>
<ul>
<li>Estimate bias with reference materials or PT/EQA material. </li>
</ul>
<p><b>Detection capability <span class="label labelimportant">NEW</span></b></p>
<ul>
<li><span style="backgroundcolor: initial;">Estimate the decision level critical value (LoB) using parametric and nonparametric estimator on blank material or via the precision profile variance function.</span><br></li>
<li>Estimate the detection limit (LoD) using nonblank material or via the precision profile variance function. </li>
</ul>
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Method validation
Releases
Tue, 23 Jun 2015 14:08:02 GMT
http://analyseit.com//blog/2015/6/analyseit40releasedsupportforclsiguidelinesandmeasurementsystemsanalysis

http://analyseit.com//blog/2014/10/asombrenoteprofessorrickjones
A sombre note: Professor Rick Jones
http://feeds.analyseit.com/~r/Analyseit/~3/NdaP5P37MqQ/asombrenoteprofessorrickjones
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<p>The recent of passing of Professor Rick Jones (see <a href="http://www.theguardian.com/education/2014/sep/09/rickjonesobituary" target="_blank">Rick Jones obituary</a>) caused me to reflect on the past.</p>
<p>I was very fortunate to earn a work placement with Dr Rick Jones at The University of Leeds in the summer of 1990. Rick was enthusiastic about the role of IT in medicine, and after securing funding for a fulltime position he employed me as a computer programmer. Early projects included software for automating the monitoring of various blood marker tests and software to diagnose Down’s syndrome. At the time many hospitals had inhouse solutions for diagnosing Down’s syndrome, and although the project took many years and the help of many other people to complete, it eventually gained widespread adoption.</p>
<p>Around 1992, Rick came up with the idea of a statistics package that integrated into Microsoft Excel. Armed with a ring bound folder containing the Excel SDK and a pile of medical statistics books, I set about the task of writing the software in C++. It wasn’t long before the first version of Astute was ready and commercially released.</p>
<p>Never short of ideas for new projects, Rick started leaving journal articles in my intray covering subjects such as Deming and PassingBablok regression, GalenGambino sensitivity/specificity and ROC analysis. Rick had widespread experience and knowledge of the statistics needed in the clinical laboratory, and was keen to make the subject less daunting and more accessible to clinicians. The plan was to extend Astute to include these new statistical techniques. It would be an entirely new type of statistics package, so new in fact that when we released the product we didn’t have a good name for it and it was simply called “Astute  Module 1”. </p>
<p><img src="http://analyseit.com/assets/article/54611637/AstuteCover.JPG"> <img src="http://analyseit.com/assets/article/54611637/AstuteMod1Contents.JPG"></p>
<p>Rick later coauthored the book <a href="http://www.amazon.co.uk/InvestigationStatisticsLaboratoryManagementTechnology/dp/0902429213" target="_blank">Clinical Investigation and Statistics in Laboratory Medicine</a> and it helped many clinicians better understand and appreciate the use of statistics in the laboratory.</p>
<p>Eventually, I moved on from Leeds University to cofound Analyseit, and develop the successor to Astute. The ‘Module 1’ product transformed into the Clinical Laboratory Module and later into the Method Validation Edition. From its conception in Astute, to its implementation to Analyseit, the product has transformed method validation in clinical laboratories and invitro diagnostic companies around the world. </p>
<p>Without Rick, Analyseit would not exist today. Rick was the original catalyst and visionary for the product. Although I am writing this with great sadness, reflecting on the past, Rick’s enthusiasm for life leaves me positive and inspired. His inspiration will live on through Analyseit.</p>
<p>Simon Huntington</p>
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Method validation
Statistics
Wed, 29 Oct 2014 11:18:58 GMT
http://analyseit.com//blog/2014/10/asombrenoteprofessorrickjones

http://analyseit.com//blog/2014/8/analyseit380releasedprincipalcomponentanalysispca
Analyseit 3.80 released: Principal Component Analysis (PCA)
http://feeds.analyseit.com/~r/Analyseit/~3/35spRJmrbTA/analyseit380releasedprincipalcomponentanalysispca
<div class="article">
<div class="content">
<p>Today we released version 3.80 of the Analyseit Standard edition.</p>
<p>The new release includes Principal Component Analysis (PCA), an extension to the multivariate analysis already available in Analyseit. It also includes probably the most advanced implementation of biplots available in any commercial package. </p>
<p>New features include:</p>
<ul>
<li>Principal Components Analysis (PCA). </li>
<li>Scree plot. </li>
<li>Classical Gabriel and modern Gower & Hand biplots. </li>
<li>Covariance and Correlation monoplots. </li>
<li>Color maps for correlations and patterned matrices, based on sign and magnitude, to help identify patterns. </li>
<li><a href="http://analyseit.com/docs/tutorials/correlation/overview" target="_blank">Tutorial (with video)</a> on how to visualize the relationships between variables and similarities between observations. </li>
</ul>
<p><img src="http://analyseit.com/assets/article/54611636/BiPlot.png"></p>
<p>The tutorial walks you through a guided example looking at how to use correlation and principal component analysis to discover the underlying relationships in data about New York Neighbourhoods. It demonstrates the amazing new features and helps you understand how to use them. You can either follow the tutorial yourself, at your own pace, or <a href="http://analyseit.com/docs/video/correlationpca" target="_blank">sit back and watch the video now</a>.</p>
<p><a href="http://analyseit.com/docs/video/correlationpca" target="_blank"><img src="http://analyseit.com/assets/article/54611636/CorrelationPCA.jpg"></a></p>
<p>If you have <a href="http://analyseit.com/docs/300/userguide/concepts/maintainance" target="_blank">active maintenance</a> you can download and install the update now, see <a href="http://analyseit.com/docs/300/userguide/concepts/softwareupdates" target="_blank">updating the software</a>. If maintenance on your licence has expired you can renew it to get this update and forthcoming updates, see <a href="http://analyseit.com/store/maintenance/" target="_blank">renew maintenance</a>.</p>
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Using Analyseit
In development
Releases
Statistics
Mon, 18 Aug 2014 12:46:05 GMT
http://analyseit.com//blog/2014/8/analyseit380releasedprincipalcomponentanalysispca

http://analyseit.com//blog/2014/6/recentimprovementsinanalyseit376andourfirstvideotutorial
Recent improvements in Analyseit 3.76 and our first video tutorial!
http://feeds.analyseit.com/~r/Analyseit/~3/DXN3lrCqQtQ/recentimprovementsinanalyseit376andourfirstvideotutorial
<div class="article">
<div class="content">
<p>If you <a href="https://www.facebook.com/analyse.it" target="_blank">follow us on Facebook</a> you will no doubt already know about the recent improvements in the Analyseit Method Validation edition and the release of our first video tutorial. If not, now is a good time to <a href="https://www.facebook.com/analyse.it" target="_blank">follow us</a> since we post short announcements and feature previews on Facebook, and use the blog only for news about major releases.</p>
<h4>What's new in release 3.76?<br>
</h4>
<p>The latest changes and improvements to the Analyseit Method Validation edition include:</p>
<ul>
<li>Extended BlandAltman Limits of Agreement (LoA) so you can calculate LoA using the ratio of measurements (for when difference between methods is related to magnitude of measurement), using linear regression (for when a transformation is not enough to eliminate the relationship between difference and magnitude), or using nonparametric percentiles (for when the differences are not normally distributed). </li>
<li>Added the <a href="http://analyseit.com/docs/userguide/methodcomparison/mountainplot" target="_blank">mountain plot</a> to method comparison so you can see the distribution of the differences. From the plot you can see the median of the differences, the central 95% interval, the range, and the percentage of observations outside the allowable error bands.</li>
<li>Added a new <a href="http://analyseit.com/docs/300/tutorials/blandaltman/overview" target="">indepth tutorial</a> to demonstrate how you can use Analyseit and the BlandAltman plot to determine the agreement between methods in various different scenarios. The tutorial is included in the software.</li>
</ul>
<p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611635/BlandAltmanRegressionLoA.png"></p>
<p>If you have <a href="http://analyseit.com/docs/300/userguide/concepts/maintainance" target="_blank">active maintenance</a> you can download and install the update now, see <a href="http://analyseit.com/docs/300/userguide/concepts/softwareupdates" target="_blank">updating the software</a>. If maintenance on your licence has expired you can renew it to get this update and forthcoming updates, see <a href="http://analyseit.com/store/maintenance/" target="_blank">renew maintenance</a>.</p>
<h4>Watch our first video tutorial!<br>
</h4>
<p>Finally, we are delighted to release our first video tutorial. The tutorial is the video equivalent of the tutorial above. It walks and talks you through using Analyseit to determine the agreement between methods. Sit back and <a href="http://analyseit.com/docs/video/blandaltmanmethodagreement">watch the video now</a>. <br>
</p>
<p><a href="http://analyseit.com/docs/video/blandaltmanmethodagreement"><img style="cursor: default;" src="http://analyseit.com/assets/article/54611635/Intro1023.jpg"></a></p>
<p>We intend to produce more video tutorials in future, so let us know what you think: what you like, dislike, and how we can improve them in future.</p>
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Method validation
Releases
Using Analyseit
Tue, 03 Jun 2014 13:15:29 GMT
http://analyseit.com//blog/2014/6/recentimprovementsinanalyseit376andourfirstvideotutorial

http://analyseit.com//blog/2014/2/analyseit370releasedimprovedmultiplecomparisonsconfidenceintervaldatabarsmeanmeanplotandsavefitmodelvariablesbacktothedataset
Analyseit 3.70 released: improved multiple comparisons, confidence interval data bars, meanmean plot, and save fit model variables back to the dataset
http://feeds.analyseit.com/~r/Analyseit/~3/CGkS3zCSgso/analyseit370releasedimprovedmultiplecomparisonsconfidenceintervaldatabarsmeanmeanplotandsavefitmodelvariablesbacktothedataset
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<div class="content">
<p>Today we released version 3.70 of Analyseit. <br>
</p>
<p>The new version includes many new features which some of you may have read about on our <a href="http://www.facebook.com/analyse.it" target="_blank">Facebook</a> page over the last few weeks:</p>
<p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611634/MultipleComparisons.png"></p>
<p>New features include:<br>
</p>
<p>Compare groups</p>
<ul>
<li>Multiple comparisons: Hsu (with best), Scheffe (all contrasts), Steel (nonparametric against control), DwassSteelCritchlowFligner (nonparametric all pairs), Wilcoxon (individual comparisons).</li>
<li>pvalue on all multiple comparisons.</li>
<li>Confidence interval data bars on Excel 2010 and later.</li>
<li>MeanMean scatter plot for visualizing multiple comparisons. </li>
</ul>
<p>Fit Model</p>
<ul>
<li>Lack of fit test for all simple regression models: Line, Polynomials, Logarithmic, Exponential, Power.</li>
<li>Maximum attainable R2 in conjunction with lack of fit test.</li>
<li>Save variables back to the dataset: Fitted Y, Residuals, Standardized Residuals, Studentized Residuals, Leverage, Cook's Influence.</li>
<li>ttest on regression coefficients.</li>
<li>Standardized beta coefficients. </li>
</ul>
<p>Correlation</p>
<ul>
<li>Covariance matrix.</li>
<li>Correlation coefficient confidence interval data bars on Excel 2010 and later.</li>
</ul>
<p>If you have <a href="http://analyseit.com/docs/300/userguide/concepts/maintainance" target="_blank">active maintenance</a> you will be notified an update is available when you next start Analyseit, or you can download and install the update now, see <a href="http://analyseit.com/docs/300/userguide/concepts/softwareupdates" target="_blank">updating the software</a>. If maintenance on your licence has expired now is a good time to renew it to get this update and forthcoming updates, see <a href="http://analyseit.com/store/maintenance/" target="_blank">renew maintenance</a>.<br>
</p>
<p>We'll go into more detail on the new features over the next few weeks. In the meantime, <a href="http://www.facebook.com/analyse.it" target="_blank">like us on Facebook</a> to get the latest news, see announcements of forthcoming features, and get handy tips on how to use the myriad of features in Analyseit.</p>
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Releases
Thu, 27 Feb 2014 13:34:49 GMT
http://analyseit.com//blog/2014/2/analyseit370releasedimprovedmultiplecomparisonsconfidenceintervaldatabarsmeanmeanplotandsavefitmodelvariablesbacktothedataset

http://analyseit.com//blog/2014/1/oursoftwaredevelopmentandvalidationprocess
Our software development and validation process
http://feeds.analyseit.com/~r/Analyseit/~3/yYx7TBsUMQM/oursoftwaredevelopmentandvalidationprocess
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<p>Probably the greatest concern when using statistical software is reliability. Is the software producing accurate, numerically correct results that have been validated?</p>
<p>It’s a very important question. Many of you work in FDA and regulated environments where the penalties for mistakes are very high. And those of you outside such environments are still making important business and research decisions using Analyseit. It’s therefore imperative that the software you depend upon is developed to a professional standard, thoroughly tested and validated. </p>
<p>Today we are publishing details of the software development and validation process we use at Analyseit, see: </p>
<p><a target="_blank" href="http://analyseit.com/support/developmentandvalidationprocess">http://analyseit.com/support/developmentandvalidationprocess</a></p>
<p>For those of you working in regulated environments the document is essential to justify the use of offtheshelf, thirdparty software. </p>
<p>For everyone else it explains exactly how Analyseit is developed, tested and validated. You can use it as a checklist against which to judge the quality of alternatives. But be wary. Professional software development is complex and developing numerical software more so. We have over 25years software development experience (each developer, not aggregate), and over 20years developing statistical software. </p>
<p>For more about our track record, see:</p>
<p><a target="_blank" href="http://analyseit.com/company/aboutus">http://analyseit.com/company/aboutus</a></p>
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In development
Business
Releases
Tue, 14 Jan 2014 14:59:07 GMT
http://analyseit.com//blog/2014/1/oursoftwaredevelopmentandvalidationprocess

http://analyseit.com//blog/2013/12/version360nowincludesrepeatmeasuresanovaandfriedmantests
Version 3.60 now includes repeatmeasures ANOVA and Friedman tests
http://feeds.analyseit.com/~r/Analyseit/~3/cwojiNVwS5E/version360nowincludesrepeatmeasuresanovaandfriedmantests
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<p>We have just released version 3.60 of the Analyseit Standard edition. It now includes repeatmeasures ANOVA and Friedman tests in the Compare Pairs analysis. </p>
<p>If you have active maintenance, Analyseit will notify you an update is available in the next few days, or you can download it immediately at:</p>
<p><a href="http://analyseit.com/support/download">http://analyseit.com/support/download</a></p>
<p>If you do not have active maintenance, now is a great time to extend maintenance to get this latest update and all updates for the next 1 or 3years, see:</p>
<p><a href="http://analyseit.com/store/FAQ#maintenance">http://analyseit.com/store/FAQ#maintenance</a></p>
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Releases
Thu, 12 Dec 2013 15:42:01 GMT
http://analyseit.com//blog/2013/12/version360nowincludesrepeatmeasuresanovaandfriedmantests

http://analyseit.com//blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable
Analyseit Method Validation edition version 3.5 is now available
http://feeds.analyseit.com/~r/Analyseit/~3/2lAWEOA4kyU/analyseitmethodvalidationeditionversion35isnowavailable
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<p>Today we released the Analyseit Method Validation edition version 3.5. The software is feature complete, validated, and includes documentation. It supports Excel 2007, Excel 2010 (32 and 64bit) and Excel 2013 (32 and 64bit). <br></p><p>We took this opportunity to rename the product from the Analyseit Method Evaluation edition to the Method Validation edition. The product is the same, but the new name better reflects the intended purpose of the product.</p><p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611631/MethodValidation.PNG"></p>
<p>New features include:</p>
<p><b>Method Comparison</b></p>
<ul>
<li>All method comparison functions: scatters plots, difference plots, and fits, are now in one place so it’s easy to make decisions or choose fits after looking at the data.</li>
<li>Ordinary linear, Weighted linear, Ordinary Deming, Weighted Deming and Passing & Bablok regressions. </li>
<li>Constant difference and relative difference plots with mean difference, allowable difference, and limits of agreement.</li>
<li>Bootstrap confidence intervals for parameters and bias in Passing & Bablok regression.</li>
<li>Exact pvalues on CUSUM linearity test.</li>
<li>Predict mean difference at decision levels.</li>
<li>Equality and equivalence hypothesis tests at decision levels.</li>
<li>Kappa and Weighted Kappa qualitative method comparison.</li>
</ul>
<p><b>Precision</b></p>
<ul>
<li>GraybillWang / TingBurdickGraybillJeyaratnamLu modified large sample confidence interval estimators for variance components – produces confidence closer to the stated level than Satterthwaite confidence intervals, which can be too liberal.</li>
<li>Support for unbalanced 1 and 2factor nested random ANOVA models, for looking at precision between days, runs, laboratories, etc.</li>
</ul>
<p><b>Linearity</b></p>
<ul>
<li>HsiehLiu confidence interval estimator for degree of nonlinearity.</li>
<li>Equality and equivalence hypothesis tests for nonlinearity.</li>
</ul>
<p><b>Reference interval</b></p>
<ul>
<li>HarrellDavis, Bootstrap, and Robust Biweight quantiles.</li>
<li>BoxCox and other transformations.</li>
</ul>
<p><b>Diagnostic performance / ROC</b></p>
<ul>
<li>Compare up to 10 independent or correlated ROC curves. </li>
<li>Equality, equivalence and noninferiority hypothesis tests.</li>
<li>Estimate false positive fraction (FPF) at fixed sensitivity, sensitivity at fixed FPF, and sensitivity/FPF at fixed cutoff.</li>
<li>Find optimal decision threshold based on costs.</li>
</ul>
<p><b>Binary diagnostic tests</b></p>
<ul>
<li>Compare sensitivity and specificity of 2 independent or correlated tests.</li>
<li>Diagnostic oddsratio and Youden’s index.</li>
<li>Improved confidence interval estimators for likelihood ratio and predictive values.</li>
</ul>
<p>For more information about the new version, and to download a free 30day trial, see:</p>
<p><a href="http://analyseit.com/products/methodvalidation">http://analyseit.com/products/methodvalidation</a></p>
<p>Pricing for the Analyseit Method Validation edition starts at US$ 699 for a 1user perpetual licence. If you already have a licence you may qualify for a free upgrade, if you have active maintenance, otherwise you can extend maintenance to get the upgrade (and all updates for 1 or 3years) free of charge. To see if you qualify for a free upgrade, otherwise get a quote to extend maintenance, see:</p>
<p><a href="http://analyseit.com/support/download">http://analyseit.com/support/download</a></p>
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In development
Method validation
Releases
Mon, 14 Oct 2013 13:44:55 GMT
http://analyseit.com//blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable

http://analyseit.com//blog/2013/8/jointheanalyseitmethodevaluation35publicbetatestandearnafreeupgrade
Join the Analyseit Method Evaluation 3.5 public beta test and earn a free upgrade!
http://feeds.analyseit.com/~r/Analyseit/~3/3flNIWCbFos/jointheanalyseitmethodevaluation35publicbetatestandearnafreeupgrade
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<h4>Update 14th October 2013</h4>
<p>The Analyseit Method Validation Edition version 3.50 has now been released, see <a href="http://analyseit.com/blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable">Analyseit Method Validation edition version 3.5 is now available</a>.</p>
<h4>Original article</h4>
<p>Today we released the first public beta test version of the Analyseit Method Evaluation edition, version 3.5. The software is feature complete and is validated – it is now only missing documentation.</p>
<p>We invite everyone to download the beta and try the new version of the software before it is finally released in September. You will need Excel 2007, 2010, or 2013 (32bit and 64bit versions are supported) and it can be installed and used alongside older versions of Analyseit so it won't interrupt your daytoday work.<br>
</p>
<p><img style="cursor: nwresize;" src="http://analyseit.com/assets/article/1/MethodComparisonScreenshot.png"></p>
<p>To download the beta version:</p>
<p><a target="_blank" href="http://analyseit.com/support/download/PTESTPKVAGWQKC7CS">http://analyseit.com/support/download/PTESTPKVAGWQKC7CS</a></p>
<p>To activate the software use the product key: </p>
<pre>PTESTPKVAGWQKC7CS</pre>
<h2>Will I qualify for a free upgrade?</h2>
<p>The software will be publically released at the end of September 2013. </p>
<p>If you purchased a licence in the last 12 months, the 12 months of maintenance included means you will qualify for a free upgrade to the new version. </p>
<p>If you are outside the 12 month free upgrade period you can purchase 12 months of maintenance, to get the upgrade (and all updates in the following year), for 20% of the cost of your licence. For example, if you have a 1user licence then the upgrade will cost 20% of the cost of a 1user licence. Similarly if you have a 3user licence the upgrade cost would be 20% of the cost of a 3user licence.</p>
<p>There is a way to reduce the cost…</p>
<h2>Earn a discount on your upgrade.</h2>
<p>The software is now validated but we would like your help to smoke out any differences in the statistics compared to Analyseit version 2.xx. To find differences, download the new release and compare the statistics against those shown by your current version of Analyseit. If you find a difference use the Send Feedback feature in the software to report the problem to us (see <a target="_blank" href="http://analyseit.com/docs/300/userguide/tasks/sendingfeedback">How to send feedback</a>).</p>
<p>If you find a difference in the statistics we will credit you $25 towards an upgrade (or new licence purchase), provided:</p>
<ul>
<li>The difference is not due to the use of a different algorithm or method. For example some statistics are now calculated using better formulas, so they will be numerically different.</li>
<li>The difference is not a small numerical difference due to a change in the order of calculation. Often a change in the order of calculation, or the splitting of computations between multiple processors, changes how rounding errors in floating point arithmetic accumulate, leading to a small difference.</li>
<li>Finally you must be using the latest release of the software. We will fix problems as they are reported and release an update that includes a fix, so please ensure you are using the latest version to avoid reporting problems that have already been fixed. Analyseit will automatically notify you of new releases, so ensure you install them as soon as possible.</li>
</ul>
<p>We will respond to every calculation problem reported. If it’s a genuine problem we will credit you US$ 25 that you can later use against the purchase of an upgrade or new licence. If it’s not a genuine problem we will tell you why (you will see the statistic does not change in later releases). There is no limit to the amount of credit you can earn, so please start testing now.</p>
<h2>Price increase from 1st September 2013.</h2>
<p>From the 1st September 2013 the price of the Analyseit Method Evaluation will increase slightly. A 1user perpetual licence will increase from US$ 649 to US$ 699, and a 1user concurrentuser perpetual licence will increase from US$ 1149 to US$ 1239. Pricing in other currencies will increase similarly.</p>
<p>The good news is you can buy a licence now, at the current prices, and the 1year maintenance included means you will get the new release (and all updates for the next year) free of charge. So if you’re considering buying a licence, or additional licences, buy now to beat the price increase.</p>
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In development
Method validation
Releases
Wed, 14 Aug 2013 12:38:36 GMT
http://analyseit.com//blog/2013/8/jointheanalyseitmethodevaluation35publicbetatestandearnafreeupgrade

http://analyseit.com//blog/2013/6/analyseitmethodevaluationedition35alpha3nowavailable
Analyseit Method Evaluation Edition 3.5 alpha 3 now available
http://feeds.analyseit.com/~r/Analyseit/~3/9gXzUDqNaVM/analyseitmethodevaluationedition35alpha3nowavailable
<div class="article">
<div class="content">
<h4>Update 14th October 2013</h4>
<p>The Analyseit Method Validation Edition version 3.50 has now been released, see <a href="http://analyseit.com/blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable">Analyseit Method Validation edition version 3.5 is now available</a>.</p>
<h4>Original article</h4><p>Today we released the 3<sup>rd</sup> alpha release of the Analyseit Method Evaluation Edition 3.5. Alpha releases are versions of the software that are still in active development, but are released to small group of customers so we can identify and fix any problems before the public beta release.</p>
<p>This release now completes the package with method comparison, which includes Deming regression, PassingBablok regression, and BlandAltman difference plots. Linearity, precision analysis, diagnostic performance (ROC analysis and binary test performance) and reference intervals were already included in earlier alpha releases.</p>
<p>If you would like to take part in this and subsequent test phases reply to this post or <a href="http://analyseit.com/company/contactus" target="_blank">contact us</a>. The test releases will run alongside any existing version of Analyseit, so your daytoday work won't be interrupted or affected. And those who help during testing will receive a discount on the upgrade (a free upgrade for those who contribute the most) when the product is released later this year.</p>
<p><img style="cursor: nwresize;" src="http://analyseit.com/assets/article/54611629/methcomp.PNG"></p>
<p><br>
</p><p>New features in the
release include:</p>
<p><b>Method Comparison</b></p>
<ul>
<li>All method comparison functions: scatters plots, difference plots, and fits, are now in one place so it’s easy to make decisions or choose fits after looking at the data.</li>
<li>Ordinary linear, Weighted linear, Ordinary Deming, Weighted Deming and Passing & Bablok regressions. </li>
<li>Constant difference and relative difference plots with mean difference, allowable difference, and limits of agreement.</li>
<li>Kappa and Weighted Kappa qualitative method comparison.<br>
</li>
<li>Bootstrap confidence intervals for parameters and bias in Passing & Bablok regression.</li>
<li>Exact pvalues on CUSUM linearity test.</li>
<li>Predict mean difference at decision levels.</li>
<li>Equality and equivalence hypothesis tests at decision levels.</li>
</ul>
<p><b>Precision</b></p>
<ul>
<li>GraybillWang / TingBurdickGraybillJeyaratnamLu modified large sample confidence interval estimators for variance components – produces confidence closer to the stated level than Satterthwaire confidence intervals, which can be too liberal.</li>
<li>Support for unbalanced 1way and 2way nested random ANOVA models.</li>
</ul>
<p><b>Linearity</b></p>
<ul>
<li>HsiehLiu confidence interval estimator for degree of nonlinearity.</li>
<li>Equality and equivalence hypothesis tests for nonlinearity.</li>
</ul>
<p><b>Reference interval</b></p>
<ul>
<li>HarrelDavis, Bootstrap, and Robust Biweight quantiles.</li>
<li>BoxCox and other transformations.</li>
</ul>
<p><b>ROC</b></p>
<ul>
<li>Compare up to 10 independent or correlated ROC curves. </li>
<li>Equality, equivalence and noninferiority hypothesis tests.</li>
<li>Estimate false positive fraction (FPF) at fixed sensitivity, sensitivity at fixed FPF, and sensitivity/FPF at fixed cutoff.</li>
<li>Find optimal decision threshold based on costs.</li>
</ul>
<p><b>Binary diagnostic tests</b></p>
<ul>
<li>Compare sensitivity and specificity of 2 independent or correlated tests.</li>
<li>Diagnostic oddsratio and Youden’s index.</li>
<li>Improved confidence interval estimators for likelihood ratio and predictive values.</li>
</ul>
</div>
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Releases
Method validation
In development
Wed, 19 Jun 2013 11:29:37 GMT
http://analyseit.com//blog/2013/6/analyseitmethodevaluationedition35alpha3nowavailable

http://analyseit.com//blog/2013/5/analyseitmethodevaluationedition35alpha2nowavailable
Analyseit Method Evaluation Edition 3.5 alpha 2 now available
http://feeds.analyseit.com/~r/Analyseit/~3/RuXmoXw1vyY/analyseitmethodevaluationedition35alpha2nowavailable
<div class="article">
<div class="content">
<h4>Update 14th October 2013</h4>
<p>The Analyseit Method Validation Edition version 3.50 has now been released, see <a href="http://analyseit.com/blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable">Analyseit Method Validation edition version 3.5 is now available</a>.</p>
<h4>Original article</h4><p>Today we released the 2<sup>nd</sup> alpha of the Analyseit Method Evaluation Edition 3.5. <br></p><p>Alpha releases are prerelease versions of the software that are still in active development. We release them to a small group of customers so we can get feedback and quickly identify and fix any problems before the public beta release. If you want to take part in the test phase reply or comment on to this post or <a href="http://analyseit.com/company/contactus" target="">contact us</a>. You can use prerelease versions of Analyseit alongside your
existing version of Analyseit, so it won't disrupt your work. And, if you help during in the test phases you will get a discount on the upgrade (a free upgrade for those who contribute the most) when the product is released later this year.</p>
<p>This latest alpha release includes linearity and precision analysis, plus diagnostic test performance (ROC analysis and binary test performance) and reference intervals from the 1<sup>st</sup> alpha. <br></p>
<p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611628/LinearityDifferencePlot.png"></p>
<p><br>Some of the new features included so far are:</p><p><b>Precision</b></p>
<ul>
<li>GraybillWang / TingBurdickGraybillJeyaratnamLu modified large sample confidence interval estimators for variance components – produces confidence closer to the stated level than Satterthwaire confidence intervals, which can be too liberal.</li>
<li>Support for unbalanced 1way and 2way nested random ANOVA models.</li>
</ul>
<p><b>Linearity</b></p>
<ul>
<li>HsiehLiu confidence interval estimator for degree of nonlinearity.</li>
<li>Equality and equivalence hypothesis tests for nonlinearity.</li>
</ul>
<p><b>Reference interval</b></p>
<ul>
<li>HarrelDavis, Bootstrap, and Robust Biweight quantiles.</li>
<li>BoxCox and other transformations.</li>
</ul>
<p><b>ROC</b></p>
<ul>
<li>Compare up to 10 independent or correlated ROC curves. </li>
<li>Equality, equivalence and noninferiority hypothesis tests.</li>
<li>Estimate false positive fraction (FPF) at fixed sensitivity, sensitivity at fixed FPF, and sensitivity/FPF at fixed cutoff.</li>
<li>Find optimal decision threshold based on costs.</li>
</ul>
<p><b>Binary diagnostic tests</b></p>
<ul>
<li>Compare sensitivity and specificity of 2 independent or correlated tests.</li>
<li>Diagnostic oddsratio and Youden’s index.</li>
<li>Improved confidence interval estimators for likelihood ratio and predictive values.</li>
</ul>
</div>
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In development
Method validation
Releases
Fri, 10 May 2013 14:45:46 GMT
http://analyseit.com//blog/2013/5/analyseitmethodevaluationedition35alpha2nowavailable

http://analyseit.com//blog/2013/4/announcingtheanalyseitmethodevaluationedition35
Announcing the Analyseit Method Evaluation Edition 3.5
http://feeds.analyseit.com/~r/Analyseit/~3/SCIiTmR9sI4/announcingtheanalyseitmethodevaluationedition35
<div class="article">
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<h4>Update 14th October 2013</h4>
<p>The Analyseit Method Validation Edition version 3.50 has now been released, see <a href="http://analyseit.com/blog/2013/10/analyseitmethodvalidationeditionversion35isnowavailable">Analyseit Method Validation edition version 3.5 is now available</a>.</p>
<h4>Original article</h4><p>We are now starting to release test previews of a major update to the Analyseit Method Evaluation edition. The new release will include many new features (we'll reveal more in the coming weeks) and will support 32 and 64bit versions of Excel 2007, 2010, and 2013.</p>
<p>During the initial test phases we release development versions of the application to a small group of customers to ensure it installs and runs as expected on a wide range of PCs and configurations. The official beta test phase stage then follows where more customers are invited to download and use the software, while we ironout the final few bugs before the official release. The official release is planned for summer 2013.</p>
<p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611627/ReferenceIntervalPreview.png"></p>
<br>
<p><img style="cursor: default;" src="http://analyseit.com/assets/article/54611627/BinaryTestPerformancePreview.png"></p>
<p>If you want to take part in the test phase, reply to this post or <a href="http://analyseit.com/company/contactus">contact us</a> and let us know what aspects of Analyseit you use:</p>
<p>Analytical Linearity, Precision, Accuracy,<br>
Diagnostic performance (ROC, binary test performance),<br>
Reference ranges,<br>
Agreement (BlandAltman). </p>
<p>We will then invite you into the testing phase at the appropriate time over the next 46 weeks. You will be able to use the test version alongside your current Analyseit so it will not disrupt your daytoday work. </p>
<p>As a reward for your time, those who partipicate in the test phases will get a discount on the upgrade (or free upgrade for those who contribute the most) when the product is released later this year.</p>
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In development
Releases
Method validation
Fri, 19 Apr 2013 15:39:36 GMT
http://analyseit.com//blog/2013/4/announcingtheanalyseitmethodevaluationedition35

http://analyseit.com//blog/2013/2/quantilespercentileswhysomanywaystocalculatethem
Quantiles, Percentiles: Why so many ways to calculate them?
http://feeds.analyseit.com/~r/Analyseit/~3/PoPNosTZLlY/quantilespercentileswhysomanywaystocalculatethem
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<p>What is a sample quantile or percentile? Take the 0.25 quantile (also known as the 25<sup>th</sup> percentile, or 1<sup>st</sup> quartile)  it defines the value (let’s call it <i>x</i>) for a random variable, such that the probability that a random observation of the variable is less than x is 0.25 (25% chance).</p>
<p>A simple question, with a simple definition? The problem is calculating quantiles. The formulas are simple enough, but a take a quick look on Wikipedia and you’ll see there are at least 9 alternative methods <a target="_blank" href="http://en.wikipedia.org/wiki/Quantile">http://en.wikipedia.org/wiki/Quantile</a>. Consequently, statistical packages use different formulas to calculate quantiles. And we're sometimes asked why the quantiles calculated by Analyseit sometimes don’t agree with Excel, SAS, or R.</p>
<h2>How are quantiles and percentiles calculated in Excel, SAS and R?</h2>
<p>Excel uses formula R7 (in the Wikipedia article) to calculate the QUARTILE and PERCENTILE functions. Excel 2010 introduced two new functions that use slightly different formulas, with different denominators: PERCENTILE.INC and PERCENTILE.EXC. </p>
<p>SAS, R and some other packages let you choose which formula is used to calculate the quantiles. While this provides some flexibility, as it lets you reproduce statistics calculated using another package, the options can be confusing. Most nonstatisticians don’t know when to use one method over another. When would you use the "Linear interpolation of the empirical distribution function" versus the "Linear interpolation of the modes for the order statistics for the uniform distribution on [0,1]" method? </p>
<h2>Why so many ways to calculate quantiles?</h2>
<p>Many of the formulas to calculate quantiles were developed when today's computing power wasn’t available. Believe it or not some are nearly 100 years old! Now they’re merely historical curiosities, but some remain in packages like SPSS that have their roots in the 1970s.</p>
<p>During the development of Analyseit we always ask: what’s the latest or best (in some sense) method we can use to calculate this statistic? </p>
<p>Filling Analyseit with all the formulas invented would be easy. But that doesn’t help the average user – users that don’t have the knowledge, or can’t invest the time needed to research the most suitable method. Instead we look at published research to find the best method. If there is no single best method we implement a small set of alternatives that provide the best solution in specific situations – situations we can clearly define and explain. </p>
<p>Every statistical test and estimator included in Analyseit has to pass this test to make the cut. We applied these principles when it came to quantiles.</p>
<p>Hyndman and Fan published a paper on calculating quantiles in 1996. It evaluated the methods used by popular statistics packages to calculate quantiles, with the intention to find a consensus on which all statistics packages could standardise. Of the 9 formulas used, 4 formulas satisfied five of the six properties desirable for a sample quantile and their derivations were deemed justified. Of those 4 formulas, Hyndman and Fan felt the "Linear interpolation of the approximate medians for order statistics" (method <a target="_blank" href="http://en.wikipedia.org/wiki/Quantile">R8 on the Wikipedia page</a>) formula was best due to the approximately medianunbiased estimates of the quantiles, regardless of the distribution. Of the remaining formulas, 2 were also distributionfree but were not unbiased, and the other was approximately unbiased only for the normal distribution. They concluded that formula R8 should be adopted as the standard across software packages. </p>
<p>That was 1996. Unfortunately little progress has since been made toward standardisation. Many statistical packages have a long history (even Analyseit is over 15years old now!) and most tend to stick to the same method to maintain backwards computability with older versions. Even R, a relative newcomer, doesn't use the recommended formula. It uses formula R7 by default, for compatibility with S (<a target="_blank" href="http://stat.ethz.ch/Rmanual/Rpatched/library/stats/html/quantile.html">http://stat.ethz.ch/Rmanual/Rpatched/library/stats/html/quantile.html</a>). Minitab, SPSS and SAS use R6.</p>
<h2>Consistency between the statistics and plots.</h2>
<p>To complicate the situation further quantiles and percentiles are also used in statistical plots. The Tukey boxplot, for example, uses the 1<sup>st</sup> and 3<sup>rd</sup> quartiles (0.25 and 0.75 quantiles) for the extent of the <i>box</i> element of the plot. </p>
<p>Frigge, Hoaglin and Iglewicz published a paper in 1989 that looked at how quantiles were calculated in 3 of the major statistical packages. They found that because each package used a different formula, each identified different observations as outliers. Confusing! They recommended statistical packages use the "Ideal or Machine Forths" formula for consistency, which is equivalent to using method R8 to calculate quartiles.</p>
<h2>What technique does Analyseit use?</h2>
<p>By now you can probably guess that we chose to use <a target="_blank" href="http://en.wikipedia.org/wiki/Quantile">R8 formula</a> in Analyseit.</p>
<p><br>
<img style="cursor: default;" alt="Analyseit uses the R8 formula (see Wikipedia) to calculate quantiles and percentile" src="http://analyseit.com/assets/article/54611626/Quantileformula.png"><br>
<br>
</p>
<p>Formula R8 is recommended as the standard in both papers cited above, for descriptive statistics and plots. And using a single formula avoids the confusing situation you’ll sometimes see with other statistics packages, where the 1<sup>st</sup> and 3<sup>rd</sup> quartiles used for the boxplot differ from sample .25 and .75 quantiles.</p>
<p>Of course using formula R8 can lead to some differences between the quantiles calculated by Analyseit and other packages, though often you'll only see it with small sample sizes. If possible, as you can in R, we recommend you change the quantile calculation to use the R8 formula. If not, you can be sure the statistics calculated by Analyseit are absolutely correct. And you can cite this article as to why!</p>
<p><b>Further reading:</b></p>
<p><a href="http://www.jstor.org/stable/2684934" target="_blank">Hyndman, R.J.; Fan, Y. (November 1996). "Sample Quantiles in Statistical Packages". The American Statistician 50 (4): 361–365. </a><br>
</p>
<p><a href="http://www.jstor.org/stable/2685173" target="_blank">Frigge, Michael; Hoaglin, David C.; Iglewicz, Boris (February 1989). "Some Implementations of the Boxplot". The American Statistician 43 (1): 50–54.</a><br>
</p>
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Using Analyseit
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Mon, 18 Feb 2013 14:39:54 GMT
http://analyseit.com//blog/2013/2/quantilespercentileswhysomanywaystocalculatethem

http://analyseit.com//blog/2013/1/analyseit310nowincludesastatisticalreferenceguide
Analyseit 3.10 now includes a statistical reference guide
http://feeds.analyseit.com/~r/Analyseit/~3/0phROt7gR3g/analyseit310nowincludesastatisticalreferenceguide
<div class="article">
<div class="content">
<p>Yesterday we improved the help in the <a href="http://analyseit.com/products/standard/" target="">Analyseit Standard Edition</a> and added a statistical reference guide. The guide tells you about the statistical procedures in Analyseit, with help on using and understanding the plots and statistics. It’s a work in progress, and we intend to improve it further with your comments and feedback, but it’s important to understand the role of the guide.</p>
<p>Firstly, the guide is not intended to be a statistics textbook. While it covers key concepts in statistical analysis, it is no substitute for learning statistics from a good teacher or textbook. </p>
<p>Secondly, the guide does not include the mathematical formulas behind the statistics. While an understanding of the mathematics is useful, it is better to understand the practical application of statistics: when and where they can be used, and how to interpret the results. Software makes it unnecessary to know the exact formulas, and often the exact mathematics used in software differ from those in textbooks since optimised routines are used to ensure good performance and numerical precision. </p>
<p>Finally, the guide does not explain experimental study design  an area where many mistakes are often made. We recommend you invest in a good textbook on study design to save wasting time on research that is ultimately flawed and cannot be published.</p><p><br><img style="cursor: default;" src="http://analyseit.com/assets/article/54611625/StatisticalReferenceGuide.png"><br><br></p><p>The Statistical Reference guide is included in version 3.10 of the Analyseit Standard Edition. If you have active maintenance you will be notified the update is available when you next start Analyseit. When you have installed the update you can access the help from the Help icon on the Analyseit tab. You can provide feedback on any topic in the help using the Send Feedback button on the toolbar within help.</p>
<p>If you prefer to read the guide on your ereader we have published it in <a href="http://analyseit.com/docs/300/UserGuide.epub" target="">EPUB format</a> (suitable for Apple iBooks and other ereaders) and <a href="http://analyseit.com/docs/300/UserGuide.mobi" target="">MOBI format</a> (suitable for Kindle readers).</p>
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http://analyseit.com//blog/2013/1/analyseit310nowincludesastatisticalreferenceguide

http://analyseit.com//blog/2012/10/analyseitstandardedition30improvementsmakeitacosteffectivealternativetotraditionalstatisticalsoftware
Analyseit Standard Edition 3.0 Improvements make it a CostEffective Alternative to Traditional Statistical Software
http://feeds.analyseit.com/~r/Analyseit/~3/IDaxQSl1LEA/analyseitstandardedition30improvementsmakeitacosteffectivealternativetotraditionalstatisticalsoftware
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<p>Leeds, England (PRWEB) October 03, 2012  Analyseit Software, Ltd. today announced a major new release of their popular <a href="http://analyseit.com/products/standard/">statistical analysis software</a>, Analyseit®. With support for Excel 2007, 2010 and the forthcoming Excel 2013, Analyseit transforms Microsoft Excel into a costeffective powerful statistical analysis and data visualization package. Statistics and plots are included for exploring and describing data, estimating parameters, testing hypotheses, uncovering relationships and fitting models. </p>
<p>"We’ve made major improvements to <a href="http://analyseit.com/products/standard/regression">model fitting and regression analysis</a> in Analyseit 3.0", said Simon Huntington, Director of Statistical Products at Analyseit. "The improvements make Analyseit a serious rival to larger statistical packages costing up to 5 times the price. Unlike the alternatives though, Analyseit lets you perform all your statistical analysis without having to leave, or export your data, from Microsoft Excel."</p>
<p>Amongst the hundreds of improvements, model fitting and regression analysis have been improved to support simple models such as linear, logarithmic, exponential and power regression and advanced models such as <a href="http://analyseit.com/products/standard/regression">multiple linear regression</a> and <a href="http://analyseit.com/products/standard/regression">logistic regression</a>. Relationships between variables can be visualized using the <a href="http://analyseit.com/products/standard/regression">scatterplot matrix</a> and partial residual leverage plots show the effect of each term when building the model. Residual plots, distribution plots, lag plots, and sequence plots are also included for checking model assumptions. And an influence plot helps to quickly identify outliers and influential points, based on Studentized residuals and Cook’s D.</p>
<p>Pricing for Analyseit 3.0 starts at just US$ 249 for a 1user perpetual licence, or US$ 99 for a 1user annual subscription. Customers with maintenance can download version 3.0 at <a href="http://analyseit.com/support/download/">http://analyseit.com/support/download/</a>, or can get the upgrade by extending maintenance from just US$ 50.<br>
</p>
<p>For more information and to download a 30day trial, visit:</p>
<p><a href="http://analyseit.com/products/standard">http://analyseit.com/products/standard/</a></p>
<p>To check if your maintenance includes a free upgrade to version 3.0, and if not to extend maintenance, visit:</p>
<p><a href="http://analyseit.com/support/download/">http://analyseit.com/support/download/</a></p>
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Wed, 03 Oct 2012 08:15:53 GMT
http://analyseit.com//blog/2012/10/analyseitstandardedition30improvementsmakeitacosteffectivealternativetotraditionalstatisticalsoftware

http://analyseit.com//blog/2012/7/analyseitstandardedition30releasecandidatenowavailable
Analyseit Standard Edition 3.0 release candidate now available
http://feeds.analyseit.com/~r/Analyseit/~3/YjKKPs_WRtU/analyseitstandardedition30releasecandidatenowavailable
<div class="article">
<div class="content">
<h4>Update 3rd October 2012</h4><p>The Analyseit Standard Edition version 3.00 is now available, see <a href="http://analyseit.com/products/standard/" target="">Analyseit Standard Edition</a> to purchase a licence or download a trial.</p><h4>Original article</h4><p>Today we pushed the release candidate of the Analyseit Standard Edition v3.0 for Microsoft Excel 2007 & 2010, our statistical analysis software for Microsoft Excel. </p><p>The release candidate is feature complete and is intended to be the final, almost public release of the software. </p><p>The software is now validated against our library of thousands of tests to ensure the statistics and plots are accurate and correct. You can now use the software in your day to day work and, like previous versions, it can be used alongside your current version of Analyseit until you become more comfortable with it. </p><p>The release candidate also includes a userguide and five tutorials to guide you through using the software by example. We recommend you complete the tutorials first as they help you quickly understand how to use Analyseit 3.0 and demonstrate many of the types of statistical analysis included. The send feedback feature is available from the help toolbar so you can easily send your suggestions on how we can improve the help.</p><p> <img alt="Tutorial help for Fit Model analysis" style="" src="https://secure.analyseit.com/assets/FitTutorial.png"></p><p>Finally the performance of the software is much improved and installation is simpler as we’ve provided a combined installer for all supported versions of Excel: Excel 2007 32bit, Excel 2010 32bit and Excel 2010 64bit. </p><p>The release candidate is available to everyone. If you already have a prerelease of Analyseit v3.0 installed you should receive an update notification in the next few days. Alternatively you can download it now at:</p><p><a href="http://analyseit.com/support/test/rc/">http://analyseit.com/support/test/rc/</a></p><p>In the next blog post we will announce pricing for Analyseit 3.0, and upgrade pricing and eligibility for current users of Analyseit. Those of you who helped during the prerelease testing of Analyseit will also be rewarded with a discount on the upgrade.</p>
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http://analyseit.com//blog/2012/7/analyseitstandardedition30releasecandidatenowavailable

http://analyseit.com//blog/2012/5/analyseitstandardedition30finalbetaandtechnicalspecification
Analyseit Standard Edition 3.0 final beta and technical specification
http://feeds.analyseit.com/~r/Analyseit/~3/qW0dUbSBZY/analyseitstandardedition30finalbetaandtechnicalspecification
<div class="article">
<div class="content">
<h4>Update 3rd October 2012</h4><p>The Analyseit Standard Edition version 3.00 is now available, see <a href="http://analyseit.com/products/standard/" target="">Analyseit Standard Edition</a> to purchase a licence or download a trial.</p><h4>Original article</h4><p>We’re pleased to release the final beta of the Analyseit Standard Edition, v3.0. The beta is now publically open to anyone as we iron out any final issues and conduct final testing before release. </p>
<p>To download the beta, please visit: </p>
<p><a href="http://analyseit.com/support/test/beta/join.aspx">http://analyseit.com/support/test/beta/join.aspx</a></p>
<p><img style="cursor: default;" alt="Influence plot for spotting influential and outlying points in fitting model." src="https://secure.analyseit.com/assets/InfluencePlot680x404.png"></p>
<p><em>Screenshot: Analyseit fit model analysis includes an influence plot to identify points with a substantial effect on the fitted model.</em></p>
<p>Many of you have asked what statistical tests and plots are included in the new release. The full specification is shown below. In coming weeks we'll announce pricing, upgrade pricing, and award free licences to the beta testers who contributed most time and effort. </p>
<table class="table">
<tbody>
<tr class="divider">
<td colspan="3">
<p>Descriptive statistics</p>
</td>
</tr>
<tr>
<td style="WIDTH: 20px"><br>
</td>
<td colspan="2">
<p>Mean, Median, Variance, SD, Skewness, Kurtosis</p>
<p>Quantiles / Percentiles</p>
<p>Frequency distribution table</p>
<p>Contingency table</p>
<p>Correlation coefficients – r, rs, tau</p>
<br>
</td>
</tr>
<tr class="divider">
<td colspan="3">
<p>Plots</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td colspan="2">
<p>Histogram</p>
<p>Frequency plot</p>
<p>Dot plot</p>
<p>Box plot</p>
<p>Mean error bar plot</p>
<p>CDF plot</p>
<p>Normal QQ plot</p>
<p>Scatter plot</p>
<p>Scatter plot matrix</p>
<p>Leverage plot</p>
<p>Residual plots</p>
<p>Outlier and influence plot</p>
<p>Difference plot</p>
<p>Mosaic plot</p>
<p>Grouped frequency plot</p>
<p>Stacked frequency plot</p>
<p>Pie frequency plot</p>
<br>
</td>
</tr>
<tr class="divider">
<td colspan="3">
<p>Hypothesis tests</p>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Location</p>
</td>
</tr>
<tr>
<td style="WIDTH: 20px"><br>
</td>
<td style="WIDTH: 20px"><br>
</td>
<td>
<p>Z</p>
<p>Student t</p>
<p>Welch t</p>
<p>Wilcoxon</p>
<p>WilcoxonMannWhitney</p>
<p>Sign</p>
<p>ANOVA</p>
<p>Welch ANOVA</p>
<p>KruskalWallis</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Dispersion</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>X<sup>2</sup></p>
<p>Fisher F</p>
<p>Bartlett</p>
<p>Levene </p>
<p>BrownForsythe</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Normality</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>ShapiroWilk</p>
<p>AndersonDarling </p>
<p>KolmogorovSmirnov</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Association</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Kendall test</p>
<p>Spearman test</p>
<p>Pearson test</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Proportions</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Binomial exact</p>
<p>McNemar exact</p>
<p>Fisher exact</p>
<p>Score Z</p>
<p>Pearson X<sup>2</sup></p>
<p>Likelihood ratio G<sup>2</sup></p>
<br>
</td>
</tr>
<tr class="divider">
<td colspan="3">
<p>Estimators</p>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Location</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Mean</p>
<p>Median</p>
<p>HodgesLehmann pseudomedian</p>
<p>tbased confidence interval for mean</p>
<p>Zbased confidence interval for mean</p>
<p>ThompsonSavur confidence interval for median</p>
<p>Tukey confidence interval for HodgesLehmann pseudomedian</p>
<p>Mean difference</p>
<p>tbased confidence interval for mean difference</p>
<p>Zbased confidence interval for mean difference</p>
<p>WelchSatterthwaite tbased confidence interval for mean difference</p>
<p>HodgesLehmann location shift</p>
<p>Tukey confidence interval for HodgesLehmann location shift</p>
<p>TukeyKramer confidence interval for mean difference</p>
<p>Dunnett confidence interval for mean difference</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Dispersion</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Variance</p>
<p>X<sup>2</sup>based confidence interval for variance</p>
<p>Variance ratio</p>
<p>Fbased confidence interval for variance ratio</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Proportions</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Proportion</p>
<p>Odds</p>
<p>ClopperPearson exact confidence interval for proportion / odds</p>
<p>Wilson score confidence interval for proportion / odds</p>
<p>Proportion difference (risk difference)</p>
<p>Proportion ratio (risk ratio)</p>
<p>Odds ratio</p>
<p>MiettinenNurminen score confidence interval for proportion difference / proportion ratio / oddsratio</p>
<p>Newcombe score confidence interval for proportion difference</p>
<p>Conditional exact confidence interval for odds ratio</p>
<br>
</td>
</tr>
<tr class="subhead">
<td><br>
</td>
<td colspan="2">
<p>Correlation</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td><br>
</td>
<td>
<p>Pearson r</p>
<p>Fisher Z confidence interval for Pearson r</p>
<p>Spearman rs</p>
<p>Kendall tau</p>
<p>SamaraRandles confidence interval for Kendall tau</p>
<br>
</td>
</tr>
<tr class="divider">
<td colspan="3">
<p class="redactorcurrenttd">Regression and model fitting</p>
</td>
</tr>
<tr>
<td><br>
</td>
<td colspan="2">
<p class="redactorcurrenttd">Linear regression</p>
<p>Polynomial 2nd to 6th order</p>
<p class="redactorcurrenttd">Logarithmic regression<br>
</p>
<p class="redactorcurrenttd">Exponential regression</p>
<p class="redactorcurrenttd">Power regression</p>
<p class="redactorcurrenttd">Multiple linear regression</p>
<p>Binary logistic regression</p>
<p class="redactorcurrenttd">Advanced multiple linear and logistic regression models with simple, crossed, polynomial and factorial terms, with categorical explanatory variables coded as dummy variables</p>
<br>
</td>
</tr>
</tbody>
</table>
</div>
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Thu, 24 May 2012 13:50:53 GMT
http://analyseit.com//blog/2012/5/analyseitstandardedition30finalbetaandtechnicalspecification

http://analyseit.com//blog/2012/3/jointheanalyseitstandardedition30beta
Join the Analyseit Standard Edition 3.0 beta!
http://feeds.analyseit.com/~r/Analyseit/~3/_nuSrqGpV0/jointheanalyseitstandardedition30beta
<div class="article">
<div class="content">
<h4>Update 3rd October 2012</h4><p>The Analyseit Standard Edition version 3.00 is now available, see <a href="http://analyseit.com/products/standard/" target="">Analyseit Standard Edition</a> to purchase a licence or download a trial.</p><h4>Original article</h4><p>Today we released the first public beta of
Analyseit Standard Edition, v3.0.</p>
<p>Maybe we're biased, but it is an amazing product! It's been a heck of a lot of work, but the range
of statistical tests and plots in Analyseit v3 rival what the expensive, established statistical packages provide. In fact, in many cases we’ve surpassed what
they offer. And the statistical plots go beyond what's available in any
other Excel addin.</p>
<p><img style="width: 680px; height: 404px; cursor: default;" src="https://secure.analyseit.com/assets/MosaicPlot680.png" align="" border="0"></p>
<p>The betatest programme is open to everyone. Even if you don't currently use Analyseit you are welcome to join. If you do use Analyseit the beta will run alongside any existing version, so your daytoday work won't be interrupted or affected.</p>
<p>To join, drop an email to <a href="http://analyseit.com/mailto:beta@analyseit.com">beta@analyseit.com</a> and <a href="http://analyseit.com/googleplus">follow us on Google+ to join the betatesting circle</a>. We will then send you a link with instructions on how to download, install and start using the software. As a reward for your time, all Google+ betatest followers will get a
discount on the upgrade when Analyseit v3.0 is launched.</p>
<p>In the coming weeks we will reveal more about Analyseit v3.0, including upgrade and new licence pricing. If you are currently considering whether to buy a licence for Analyseit v2.0, don’t hesitate – you’ll get the upgrade to version 3.0 free of charge and avoid the price increase.</p>
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In development
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Fri, 02 Mar 2012 14:57:22 GMT
http://analyseit.com//blog/2012/3/jointheanalyseitstandardedition30beta